Enceladus’ platform technology combines liposomes and corticosteroids. The steroid containing liposomes selectively accumulate in inflamed tissues and in tumors after intravenous injection. This effect occurs by virtue of the local increased permeability of blood vessel walls, a phenomenon that is normally found at inflamed and malignant sites. The liposomes are small (< 150 nm) vesicles comprising a lipid bilayer that contains specific phospholipids in combination with cholesterol. The corticosteroid, which forms the actual anti-inflammatory content, is dissolved in the aqueous interior and remains entrapped inside. Enceladus can encapsulate various corticosteroid with different characteristics in order to address specific requirements for various indications.

 

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